生化制药厂的老板Franklin(塞缪尔·杰克逊 Samuel L. Jackson 饰)提供大量资金供让Susan McAlester博士(萨弗蓉·布罗斯 Saffron Burrows 饰)研究抗老年痴呆症的药物。Susan和研究小组在设备精良的海底研究中心,提取鲨鱼脑中蛋白质,注入坏死的人类脑细胞。为了可以提取到萃取更多的鲨鱼脑蛋白,Susan也同时加大了鲨鱼们的脑容量。这一举动让本来作为试验品的鲨鱼们变得更为强壮和聪明。鲨鱼专家Carter(托马斯·简 Thomas Jane 饰)因和鲨鱼们朝夕相处时发现了鲨鱼们的异样,并向Susan提出了警告,却得到了Susan的无视。终于,在最后一次验中,那些曾经沦为人类试验品的凶残鲨鱼们向人类展开报复……
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1300:43:01.745 : Chapter 1400:46:54.394 : Chapter 1500:50:59.389 : Chapter 1600:54:42.570 : Chapter 1700:57:23.731 : Chapter 1801:01:41.364 : Chapter 1901:04:23.943 : Chapter 2001:08:35.361 : Chapter 2101:12:09.867 : Chapter 2201:15:13.091 : Chapter 2301:16:08.814 : Chapter 2401:18:00.509 : Chapter 2501:19:55.749 : Chapter 2601:23:44.352 : Chapter 2701:26:14.502 : Chapter 2801:28:44.819 : Chapter 2901:31:19.056 : Chapter 3001:33:42.158 : Chapter 3101:35:31.058 : Chapter 3201:37:36.892 : Chapter 33