某飞机失事后109名乘客仅数名幸存。心理医生克莱尔(安妮•海瑟薇Anne Hathaway 饰)被导师派去对幸存者进行心理治疗,却发现自己渐渐爱上幸存者之一,前证券公司副总裁艾瑞克(帕特里克•威尔森 Patrick Wilson 饰)。与此同时,克莱尔发现诊所外经常有人监视,自己被跟梢,病人神秘失踪,甚至航空公司职员也来威胁她不要多管闲事,这令克莱尔怀疑航空公司为掩盖机械故障的事实,故意用操作失误来掩人耳目避免调查,进而对察觉真相的幸存乘客施以毒手。随着克莱尔与艾瑞克感情的深入,病人竟变得越来越少,克莱尔与姐姐一家也失去联络,甚至就连她的自身安全也面临威胁……
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