《美版中毒》改编2002年李秉宪与李美妍主演的同名韩国电影《中毒》。
一场交通事故,让杰西卡(莎拉·米歇尔·盖拉 Sarah Michelle Gellar 饰)的丈夫瑞恩(迈克尔·兰德斯 Michael Landes 饰)和小叔子瑞曼(李·佩斯 Lee Pace 饰)陷入昏迷,并被告知又变成植物人的危险。但在数月后瑞曼先醒了过来,这使杰西卡看到了丈夫也康复如初的一线希望。而瑞曼竟对杰西卡说,他就是丈夫瑞恩。开始杰西卡并没有相信,但瑞曼的处事方法越来越像瑞曼,并说了很只有瑞恩才知道的秘密。杰西卡陷入了深深的矛盾之中:一方面她难以接受和灵魂的转移;另一方面,她又感觉到了丈夫的气息和模糊的幸福。似乎如同中毒一般不可救药的爱情就要开始了。而与此同时,医院内的瑞恩似乎有了复苏的迹象……
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